A motorway bridge has collapsed in the northwest Italian city of Genoa, sending vehicles plummeting up to 90m (295ft) to the ground and killing at least 22 people, officials say.
Video footage appears to show one of the towers holding up the suspension bridge collapsing in stormy weather.
Vehicles fell along with bridge debris on to rail tracks and a warehouse.
Emergency workers are trying to free people caught in crushed vehicles or rubble, and are using sniffer dogs.
Transport Minister Danilo Toninelli spoke of an “immense tragedy” and France offered Italy its support.
Shares in Atlantia, the toll road operator which runs much of the country’s motorways, fell 6.3% after news of the collapse.
French President Emmanuel Macron has tweeted a message of sympathy to the people of Italy, writing in both Italian and French. He said France was ready to offer any necessary aid.